During my 29 years in practice, there have only been a handful of very exciting nutritional developments. Most of the valuable focuses and products were developed by the time I started in practice in 1984. One of these rare moments has developed over the last year: having a solution for the many people challenged by a Methylation pathway deficiency.
The Methylation pathway is a bio-chemical process that occurs in every cell of our body and is essential for many critical functions. However, nearly 40% of the population contains genetic variances affecting this process. Luckily, we NOW have a solution to this problem: a new supplement called 5 MTHF (5-Methyltetrahydrofolate), which is the end product produced by the methylation cycle. When combined with critical co-factors and skillful dosage management, we get an effective treatment for this genetic challenge.
The most common nutritionally based genetic defect affects the Methylation cycle by decreasing the amount of 5 MTHF our cells make. If an individual has just one or two of these genetic defects, their pathway can only produce 40 - 70% of the necessary 5 MTHF that a normal pathway produces.
5 MTHF and the methylation pathway are crucial for numerous bio-chemical processes, including the production of Serotonin, Dopamine, Norepinephrine and Methionine. Methylation also increases our natural Melatonin, SAMe and Glutathione production, lowers Homocysteine and histamine levels, clears heavy metals and detoxifies many chemicals and hormones. The cycle contributes to the insulation around our nerves (myelination), regulates gene expression (activating the beneficial, while suppressing corrupt genes) and creates RNA and DNA, the building blocks of our cells.
We now have the important form of folate these patients need, available in supplemental form, 5 MTHF. When taken at the right dose and with the proper co-factors, those with these genetic defects can overcome the adverse affects associated with their methylation deficiency! This offers a very exciting outcome for these patients, which I am very excited about, as they often have challenging, stubborn issues and diseases, which can be irreversible. Having a solution to this problem is huge when you understand the depth and breadth of everything it can affect.
Here is a list of symptoms and diseases that may be related to 5 MTHF deficiency. (please note, most patients who have this problem may have just one, or a few of these symptoms, some will have many):
Depression Mild-Severe (if one has this genetic challenge, the change in their depression is distinctly noticeable with our program and within a short period of time).
High Homocysteine levels
Histamine excess (allergies)
Restless Leg Syndrome (RLS)
Addictive behavior tendencies
Chronic Fatigue Syndrome
Multiple Chemical sensitivities
Severe or Frequent Infections
Hearing loss that is nerve related.
Dysgeusia (Loss of Taste)
Cardio Vascular Dis. (Heart Attack, Stroke, deep vein thrombosis, peripheral vascular disease, high blood pressure, low HDL, Stroke)
There are two approaches to determining whether one may have this issue, either genetic testing, or reviewing the associated symptoms. If you have any of the above symptoms that are persistent, I'll have you begin taking 5 MTHF, plus co-factors, and watch to see if you have a favorable response. Many of the most common symptoms respond favorably, and in a noticeable way within 1 - 4 weeks.
It is important that this be done using a very specific approach, a carefully chosen dose, plus critical co-factors, and then carefully tracking the response. The good news is that most of my patients are already taking the co-factors as part of their nutritional program with me.
In just the past 2 months of working on this condition with a limited number of patients, we have seen many favorable responses, especially those related to mood (including chronic depression and anxiety), sleep, and circulation.
If you have any of the symptoms in the columns above, and want to see if you can benefit from this genetic challenge being addressed, call for an appointment. It is quite simple for us to proceed within one visit.
If you know of anyone who has some of these symptoms and would like to determine if they may have this issue, please have them call for a New Patient exam.
Important Caution: In some rare cases, an individual may have excessive toxins accumulated due to prolonged dysfunction of the methylation pathway and can begin to detox too quickly and experience side effects. I have not seen this yet, but again, most of my patients have been on products that have supported their detox pathways to work at a higher level than the average person. This detox reaction is reversible. Additionally, no one should just start taking 5 MTHF on their own, as severe negative reactions can happen to some people if their co-factors are not managed properly.
This product is not safe for anyone taking Anti-Seizure drugs or Methotrexate.
If you are interested in genetic testing to see if you have this issue, please contact me at [email protected]